diff --git a/build/runner/src/pyenv.rs b/build/runner/src/pyenv.rs
index f514096fb..9d65626ca 100644
--- a/build/runner/src/pyenv.rs
+++ b/build/runner/src/pyenv.rs
@@ -32,9 +32,17 @@ pub fn setup_pyenv(args: PyenvArgs) {
         }
     }
 
+    let mut command = Command::new(args.uv_bin);
+
+    // remove UV_* environment variables to avoid interference
+    for (key, _) in std::env::vars() {
+        if key.starts_with("UV_") {
+            command.env_remove(key);
+        }
+    }
+
     run_command(
-        Command::new(args.uv_bin)
-            .env_clear()
+        command
             .env("UV_PROJECT_ENVIRONMENT", args.pyenv_folder.clone())
             .args(["sync", "--locked", "--no-config"])
             .args(args.extra_args),
diff --git a/qt/launcher/src/main.rs b/qt/launcher/src/main.rs
index 34a81a622..15548d3bc 100644
--- a/qt/launcher/src/main.rs
+++ b/qt/launcher/src/main.rs
@@ -257,9 +257,16 @@ fn handle_version_install_or_update(state: &State, choice: MainMenuChoice) -> Re
 
     // Prepare to sync the venv
     let mut command = Command::new(&state.uv_path);
+    command.current_dir(&state.uv_install_root);
+
+    // remove UV_* environment variables to avoid interference
+    for (key, _) in std::env::vars() {
+        if key.starts_with("UV_") {
+            command.env_remove(key);
+        }
+    }
+
     command
-        .current_dir(&state.uv_install_root)
-        .env_clear()
         .env("UV_CACHE_DIR", &state.uv_cache_dir)
         .env("UV_PYTHON_INSTALL_DIR", &state.uv_python_install_dir)
         .args(["sync", "--upgrade", "--managed-python", "--no-config"]);