diff --git a/qt/aqt/clayout.py b/qt/aqt/clayout.py
index 00e86ab0f..fbc414a38 100644
--- a/qt/aqt/clayout.py
+++ b/qt/aqt/clayout.py
@@ -491,12 +491,14 @@ class CardLayout(QDialog):
             self.have_autoplayed = True
 
             if c.autoplay():
+                AnkiWebView.setPlaybackRequiresGesture(False)
                 if self.pform.preview_front.isChecked():
                     audio = c.question_av_tags()
                 else:
                     audio = c.answer_av_tags()
                 av_player.play_tags(audio)
             else:
+                AnkiWebView.setPlaybackRequiresGesture(True)
                 av_player.clear_queue_and_maybe_interrupt()
 
         self.updateCardNames()
diff --git a/qt/aqt/previewer.py b/qt/aqt/previewer.py
index c1da2a289..d11853778 100644
--- a/qt/aqt/previewer.py
+++ b/qt/aqt/previewer.py
@@ -184,6 +184,7 @@ class Previewer(QDialog):
             bodyclass = theme_manager.body_classes_for_card_ord(c.ord)
 
             if c.autoplay():
+                AnkiWebView.setPlaybackRequiresGesture(False)
                 if self._show_both_sides:
                     # if we're showing both sides at once, remove any audio
                     # from the answer that's appeared on the question already
@@ -198,6 +199,7 @@ class Previewer(QDialog):
                     audio = c.answer_av_tags()
                 av_player.play_tags(audio)
             else:
+                AnkiWebView.setPlaybackRequiresGesture(True)
                 av_player.clear_queue_and_maybe_interrupt()
 
             txt = self.mw.prepare_card_text_for_display(txt)
diff --git a/qt/aqt/reviewer.py b/qt/aqt/reviewer.py
index 15045dc59..dd2202212 100644
--- a/qt/aqt/reviewer.py
+++ b/qt/aqt/reviewer.py
@@ -23,6 +23,7 @@ from aqt.sound import av_player, getAudio, play_clicked_audio
 from aqt.theme import theme_manager
 from aqt.toolbar import BottomBar
 from aqt.utils import askUserDialog, downArrow, qtMenuShortcutWorkaround, tooltip
+from aqt.webview import AnkiWebView
 
 
 class ReviewerBottomBar:
@@ -183,10 +184,12 @@ class Reviewer:
         q = c.q()
         # play audio?
         if c.autoplay():
+            AnkiWebView.setPlaybackRequiresGesture(False)
             sounds = c.question_av_tags()
             gui_hooks.reviewer_will_play_question_sounds(c, sounds)
             av_player.play_tags(sounds)
         else:
+            AnkiWebView.setPlaybackRequiresGesture(True)
             av_player.clear_queue_and_maybe_interrupt()
             sounds = []
             gui_hooks.reviewer_will_play_question_sounds(c, sounds)
diff --git a/qt/aqt/webview.py b/qt/aqt/webview.py
index ea4b37844..75f3fc59c 100644
--- a/qt/aqt/webview.py
+++ b/qt/aqt/webview.py
@@ -340,6 +340,12 @@ class AnkiWebView(QWebEngineView):
         newFactor = desiredScale / qtIntScale
         return max(1, newFactor)
 
+    @staticmethod
+    def setPlaybackRequiresGesture(value: bool) -> None:
+        QWebEngineSettings.globalSettings().setAttribute(
+            QWebEngineSettings.PlaybackRequiresUserGesture, value
+        )
+
     def _getQtIntScale(self, screen) -> int:
         # try to detect if Qt has scaled the screen
         # - qt will round the scale factor to a whole number, so a dpi of 125% = 1x,